All mammals have around 25,000 genes, yet humans are by far the most sophisticated. Our similar number of genes can code advanced processes because humans utilize thousands of commensal gut bacteria species to produce the precursors and chemical intermediates of human protein. Some bacteria even work in concert to produce a useful molecule. Human genes appear to begin few processes from absolute scratch. However, there may be a downside to these bacteria. In 1907, Metchnikoff theorized that rouge bacteria colonization of the colon was the cause of aging.
A decline in physical protein structure and increasing loss of function define aging. Diseases of aging are easily explainable by lack of collagen, peptides and hormones. All of these are proteins and formed with the complete supply of all twenty amino acids. Lack of a single amino acid is enough to prevent protein production. After all, RNA cannot code for protein without availability of all needed amino acids. Borrowing of amino acids from structure to continue life becomes the first visible sign of aging.
Madame Jeanne Calment lived to the age of 123. Her sole unusual habit was to consume a bottle of port wine each night within an extended suppertime. This must have had an affect on longevity as none of her relatives were as long lived. In 2012, a molecule was isolated. This compound evidently naturally forms from extended contact of alcohol with the only amino acid that is soluble in alcohol. The combination allows the amino acid to be quickly absorbed. This circumvents the uptake and use by the already trillions of commensal gut bacteria normally associated with senior adults.
The new theory becomes that explosive growth of gut bacteria is the trigger of aging. Accordingly, exponential growth of gut bacteria would utilize all available amino acid nutrition in the colon. The orthodoxy states that bacteria produce their own supply of amino acids. The new theory supposes that rogue bacteria could evolve to utilize under utilized amino acids. It is a critical function that lymph circulates amino acids from the intestine to the lymph nodes. While not as acutely critical as circulation of oxygen and glucose by the heart, removing nutrition from the colon becomes critical. As muscle movement alone circulates lymph, stagnation caused by the lack of exercise promotes growth of rogue bacteria. Aging results from a lack of amino acid nutrition.
The Metchnikoff theory was abandoned because researchers of the day could not isolate the ”toxin” they believed responsible. There is still unwavering faith in existing orthodoxy. When this research began, the amino acid cited above was considered non-essential. It has only lately being accepted as conditionally essential. Obviously it is essential. It is widely distributed in the literature that four specific amino acids may not be well absorbed with age. It is now obvious that these, early on, are broken down in the intestine to prevent the rouge bacteria from obtaining all 20. The body seems to accept the slow decline of aging as to prevent a certain death by explosive infection.
An application for US patent on potential cures for diseases of aging was filed in 2012. Useful products are in the pipeline.